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We believe that by capitalizing on various critical contributions to the understanding of the AR structure and function and advancements in crystallography techniques, the future of rational drug design for better antiandrogens for the treatment of prostate cancer remains bright

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The mild elevation of -BB, coupled with a conserved amino acid change, suggests that D72G is a hypomorphic, milder variant resulting in a quantifiable metabolic phenotype where small deviations in -BB levels are metabolically tolerable in C

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[DOI] [PMC free article] [PubMed] [Google Scholar] 221.Smith AD, Kim YI, Refsum H